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KMID : 0388220140210030162
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 3 p.162 ~ p.165
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A Case of Propylthiouracl induced Anti-neutrophil Cytoplasm Antibody Positive Pyoderma Gangrenosum
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Lee Ji-Yeon
Lee Ji-Min
Lee Tae-Hwan
Jeong Hye-Jin
Choi Go
Chae Jin-Nyeong
Kim Ji-Min
Kim Sang-Hyun
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Abstract
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Pyoderma gangrenosum (PG) is a rare disease that causes chronic skin ulcers, and it has recently been known to be related to changes in the immune system such as dysfunc-tion of neutrophils. Over 50% of patients with PG have an underlying systemic disease, and rarely are there various medicines causing the disease, including iodide, bromide, and isotretinoin. A 49-year-old man had recurrent skin ul-cers in his lower extremities. He had a history of taking propylthiouracil (PTU) for 10 years as a treatment for Graves’ disease. Here, we describe a case of PTU-induced ANCA positive PG in a patient with hyperthyroidism, who has been improved after the cessation of PTU.
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KEYWORD
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Pyoderma gangrenosum, Propylthiouracil, ANCA
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